When creating a VPG, a customer may want to fully exclude a drive so it doesn't get replicated to the target site.    




   The drive itself may be very large in size and may take up most of the networking pipe    




In terms of excluding an actual drive, there is no official way to do such however we have a workaround where you can set that drive as "temp". When a drive is set as a temp it will do a initial sync however, it will not replicate any other changes from that drive to the DR site. Meaning once the initial sync completes, that volume will no longer replicate any IOs to the recovery volumes in the DR site. 
To set the volume as temp please edit VPG (storage tab->check "temp").